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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC1
All Species:
44.24
Human Site:
Y358
Identified Species:
64.89
UniProt:
Q13547
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13547
NP_004955.2
482
55103
Y358
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Chimpanzee
Pan troglodytes
XP_519834
482
55098
Y358
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Rhesus Macaque
Macaca mulatta
XP_001096929
485
54378
Y367
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Dog
Lupus familis
XP_544435
482
55144
Y358
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Cat
Felis silvestris
Mouse
Mus musculus
O09106
482
55056
Y358
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Rat
Rattus norvegicus
Q4QQW4
482
55074
Y358
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
Y355
T
N
Q
N
T
P
E
Y
M
E
K
I
K
Q
R
Chicken
Gallus gallus
P56517
480
54920
Y358
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Frog
Xenopus laevis
O42227
480
54874
Y358
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
F332
Y
S
E
Y
F
E
Y
F
A
P
D
F
T
L
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
Y356
T
N
Q
N
T
S
E
Y
L
E
K
I
K
N
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
M362
A
N
E
N
S
S
D
M
L
A
K
L
Q
T
D
Sea Urchin
Strong. purpuratus
P56518
576
64060
Y357
T
N
Q
N
T
G
E
Y
L
D
K
I
K
T
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
Q371
E
N
K
N
T
R
Q
Q
L
D
D
I
R
S
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22446
501
56004
M366
E
N
K
N
S
R
Q
M
L
E
E
I
R
N
D
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
P339
V
V
L
D
K
D
L
P
Y
N
E
Y
Y
E
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
88.4
99.1
N.A.
99.3
99.1
N.A.
83.4
93.3
91
54.3
N.A.
71.9
N.A.
59.5
69.6
Protein Similarity:
100
100
90.7
99.5
N.A.
100
100
N.A.
89
96.4
96.8
71.3
N.A.
82.1
N.A.
77.5
77.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
86.6
100
100
0
N.A.
86.6
N.A.
26.6
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
100
20
N.A.
93.3
N.A.
66.6
86.6
Percent
Protein Identity:
N.A.
53.2
N.A.
56.6
54.5
N.A.
Protein Similarity:
N.A.
69.9
N.A.
71
70.1
N.A.
P-Site Identity:
N.A.
33.3
N.A.
33.3
0
N.A.
P-Site Similarity:
N.A.
66.6
N.A.
66.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
7
7
0
0
13
13
0
0
0
13
% D
% Glu:
13
0
13
0
0
7
69
0
0
69
13
0
0
7
0
% E
% Phe:
0
0
0
0
7
0
0
7
0
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
82
0
0
0
% I
% Lys:
0
0
13
0
7
0
0
0
0
0
75
0
69
0
7
% K
% Leu:
0
0
7
0
0
0
7
0
82
0
0
7
0
7
0
% L
% Met:
0
0
0
0
0
0
0
13
7
0
0
0
0
0
0
% M
% Asn:
0
88
0
88
0
50
0
0
0
7
0
0
0
13
0
% N
% Pro:
0
0
0
0
0
7
0
7
0
7
0
0
0
0
0
% P
% Gln:
0
0
69
0
0
0
13
7
0
0
0
0
7
57
0
% Q
% Arg:
0
0
0
0
0
13
0
0
0
0
0
0
13
0
69
% R
% Ser:
0
7
0
0
13
13
0
0
0
0
0
0
0
7
0
% S
% Thr:
69
0
0
0
75
0
0
0
0
0
0
0
7
13
0
% T
% Val:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
7
0
0
7
69
7
0
0
7
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _